High Carotenoid Dietary Intake Increases Leukocyte Telomere Length

High Carotenoid Dietary Intake Increases Leukocyte Telomere Length


A new study demonstrates increased level of blood carotenoids (ie: high consumption of carotenoid-rich foods) increases telomere length. Telomere length is a biomarker for age-related diseases. Hence, shorter telomere length is associated with aging, cancer and a higher risk of developing age-related disease and vice versa.

In this study, 3660 participants aged 20-year-old and above US adults were recruited in the 1999-2002 National Health and Nutrition Examination Survey (NHANES). The concentration of carotenoids (alpha-carotene, beta-carotene (trans + cis), beta-cryptoxanthin, combined lutein/zeaxanthin and trans-lycopene) were measured by high-performance liquid chromatography. DNA samples were extracted from whole blood and the leukocyte telomere length (T/S ratio), which was determined by the ratio of telomere repeat copy number (T) to the single-copy gene (S) copy number (T/S ratio) as control to normalize DNA.

From the results, it was found that blood alpha-carotene, beta-carotene (trans+ cis) and beta-cryptoxanthin were significantly associated with 1.76%, 2.22% and 2.02% longer telomeres respectively. However blood lutein/zeaxanthin and trans-lycopene did not show any statistical significance. Additionally, when comparing to the lowest carotenoid (alpha-carotene, beta-carotene (trans+ cis) and beta-cyptoxanthin) quartiles, the telomere length increased from 5-8% in the highest carotenoid quartiles.

“Telomeres are specialized structures at the end of the chromosomes to protect the loss of our genetic data during cell division. Unfortunately, the length of the telomeres shortens each time after cell division and the shortening process is associated with aging, cancer and a higher risk of death. Hence, it is crucial to preserve the length of telomeres to ensure proper cell functions. The length of the telomere determines the life expectancy of the cell by regulating the number of replications that a cell undergoes. The results from this study is very encouraging as high dietary intakes of carotenoids especially alpha-carotene and beta-carotene increase telomere lengths, which suggests reduced aging and risks for age-related diseases or better health,” says CheeYen Lau, Nutritionist at ExcelVite.

“This study highlights the importance of attaining high content of carotenoids from natural diets to minimize aging and age-related health problems. High intake of carotenoids can be achieved via dietary supplements, as a convenient way to help increase the plasma concentration of carotenoids. EVTene™ is the only true natural mixed carotenoid complex, concentrated from the fruit of oil palm. What makes it interesting is that it has similar carotenoid composition as carrots and thus, it is a true natural source of alpha-and beta-carotene,” says Bryan See, Regional Product Manager, ExcelVite. “Additionally, food and beverage companies may consider fortifying food products with EVTene™ (as a natural colorant) for its added health benefits to their consumers,” added Bryan.

Min, KB. & Min JY. (2016). Association between leukocyte telomere length and serum carotenoid in US adults. Eur J Nutr. doi:10.1007/s00394-016-1152-x.


Disclaimer: The statements in the above article have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure or prevent any disease.