20 Years of Palm Tocotrienol and Brain Health Research

Tocotrienol & Brain Health

Our Brain acts as a control center that regulates our body biological events such as respiration and metabolism processes. The brain contains high content of polyunsaturated fatty acids (PUFAs), making it very susceptible to free radical-mediated oxidative stress that negatively affects brain health [1]. When compared to other organs, the brain requires higher amount of oxygen to cater for its metabolic demand [2]. However, this also would lead to higher risk of oxidative stress towards the PUFAs which in turn could damage the neuron. Therefore, lipid soluble antioxidants such as vitamin E (Tocopherols and Tocotrienols) are crucial to minimize oxidative stress and support healthy brain function.

The first neuroprotective action of tocotrienol was reported back in year 2000 where extremely low concentration of alpha-tocotrienol (nanomolar, 10-9) promoted complete recovery of neurons even when alpha-tocotrienol was introduced several hours after the glutamate-induced injury [3]. Interestingly, this benefit was not observed in the commonly-studied alpha-tocopherol. This promising result marked a significant turning point in tocotrienol’s research because researchers and scientists then started to investigate the benefits of tocotrienol in promoting healthy brain function.

Tocotrienol’s research on brain health has moved from in-vitro studies to pre-clinical study and currently, human clinical study; in the span of 20 years. These research studies on brain health were conducted specifically on a full spectrum palm tocotrienol complex called EVNol™ and also on the bioenhanced form of palm tocotrienol complex called EVNol SupraBio™, an oral formulation for softgel dosage form that guarantees at least 2.5 times better tocotrienol absorption in the human digestive system [4].

To celebrate 20 years of full spectrum palm tocotrienol brain health research, a collection of resources are added to this page so that readers will have a better understanding on how this special form of palm vitamin E address important brain health matters.

There is nothing more interesting than getting firsthand information from the researchers who were involved in the studies. Hence, here is a series of videos from an interview session with Prof. Chandan Sen, the lead researcher and pioneer for palm tocotrienol’s brain health research.

Part I : Prof. Chandan Sen reviewed palm tocotrienol’s properties and its potential

Part II : Prof. Chandan Sen discussed palm tocotrienol’s research phases based on FDA’s clinical trial

Part III : Prof. Chandan Sen shared the potential of palm tocotrienol in brain health

Part IV : Prof. Chandan Sen shared the safety and side effect findings of palm tocotrienols

Part V : Prof. Chandan Sen explained whether tocotrienol can be taken together with Plavix (a blood thinner)


Click on each image to view enlarged version


  1. Plant Foods Hum Nutr 57:319-341, 2002.
  2. Cambridge University Press, 2000.
  3. The Journal of Biological Chemistry, 275 (17), 13049-13055, 2000.
  4. U.S. Patent No. 6,596,306.