A randomized, double-blinded, placebo-controlled trial was conducted by a group of researchers from the School of Medicine and Health Sciences, Monash University Malaysia, to investigate the effect of EVNol SupraBio™ on diabetic nephropathy (also known as diabetic kidney disease). The study (1) is published in the high-impact journal, Nutrients, focusing on diabetic nephropathy, one of the major complications for diabetes and the leading cause of end stage renal failure worldwide.

In general, kidney damage rarely happens in the first 10 years of diabetes. Kidney failure usually happens 15 to 25 years after the first symptoms of diabetes. Since diabetic nephropathy take many years to develop, 45 patients with type 2 diabetes for an average of 18.5 years were selected for this study. Their microalbuminuria-positive result were ensured to be due to diabetic nephropathy alone (microalbuminuria is an early sign for kidney disease). They were randomly divided into 2 groups:

  • Placebo group
  • Intervention group receiving EVNol SupraBio™

The blood serum of the patients were measured at baseline and after a short 8-weeks supplementation of either 400 mg/day EVNol SupraBio™ or placebo.

EVNol SupraBio™ bioenhanced full spectrum palm tocotrienol complex, significantly reduced serum creatinine level hence potentially averting the progression of renal impairment among the diabetic nephropathy patients.

No significant changes were observed in the level of HbA1c, serum AGE, sRAGE, Nε-CML and Cystatin C in the diabetic nephropathy patients in this study. This was the opposite to a previous study (2) on newly-induced diabetic rat model that showed supplementation of EVNol SupraBio™ significantly reduce the aforementioned biomarkers. As per the researchers, the lack of significant effects observed in this study could be due to the long duration of diabetes among the patients (average 18.5 years), causing a long-term and difficult-to-reverse accumulation of these biomarkers in the body. This might have hindered the reduction and led the researchers to recommend a longer supplementation time for the tocotrienol to take effect.

Nevertheless, supplementation of EVNol SupraBio™ – bioenhanced full spectrum palm tocotrienol complex – significantly reduced serum creatinine compared to placebo. Therefore, the researchers concluded that EVNol SupraBio™ may be useful in addition to the current treatment for diabetic nephropathy.

 “Tocotrienol has been proven to have 40 – 60 times more potent antioxidant activity compared to tocopherol and has superior anti-inflammatory, neuroprotective and cardioprotective properties. However, the renoprotective effect of tocotrienol in type 2 diabetes patient is currently limited and we are glad the researchers choose EVNol SupraBio™ to investigate the effect of tocotrienol in delaying diabetic nephropathy,” Says Diyanah Roslan, Nutritionist at ExcelVite.

 “The number of people affected by diabetes continue to increase by the year, and it is vital to search for the right remedy to help delay diabetic complications, such as diabetic nephropathy. We are glad this study demonstrates the efficacy of EVNol SupraBio™ in reducing creatinine level specifically, which potentially could slow down the progression of diabetic nephropathy.” 


  1. Suzanne May Quinn Tan, Yilynn Chiew, Badariah Ahmad and Khalid Abdul Kadir. (2018). Tocotrienol-rich vitamin E from palm oil (Tocovid) and its effects in diabetes and diabetic nephropathy: A pilot phase II clinical trial. Nutrients, 10(9). doi:10.3390/nu10091315.
  2. Cheng HS, et al. (2017). The ameliorative effects of a tocotrienol-rich fraction on the AGE-RAGE axis and hypertension in high-fat-diet-fed rats with metabolic syndrome. Nutrients, 9(9). doi:10.3390/nu9090984.



Disclaimer: The statements in the above article have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure or prevent any disease.