Researchers at the Ohio State University Wexner Medical Center discovered a novel pathway for hair follicular regeneration with tocotrienols. EVNol SupraBio™ – patented & bioenhanced full spectrum palm tocotrienol complex is shown to upregulate the gene expressions of the “Yamanaka Transcription Factors”, leading to increased fetal characteristics of hair follicular development and promoting anagen hair cycling.
The researchers reported the following findings in the tocotrienol treated mice:
- Significantly increased number of anagen hair follicles;
- Increased epidermal keratinocyte proliferation;
- Significant decreased E-cadherin expression that was associated with high translocation of beta-catenin-Tf3; causing
- Upregulation of the Oct4, Sox9, Klf4, c-Myc and Nanog skin-specifc pluripotent factors;
Ultimately resulting in hair follicular regeneration.
“What we have shown is that Palm TRF can induce hair folliculogenesis, which means that it can enrich the skin stem cell reserves. This novel epidermal pathway of hair follicular regeneration can have widespread impact on skin function including skin aging and repair,” says Prof. Chandan Sen, the lead researcher at Ohio State University Wexner Medical Center.
A previous 2010 human study shows that supplementation with EVNol SupraBio™ at 100mg/day for 8 months leads to improved hair growth in subjects with hair loss issues.
“We are thrilled with this new discovery, especially this novel pathway that affirmed our previous clinical findings for EVNol SupraBio™ in hair growth, (US Patent No: 7,211,274; Trop. Life Sci. Res. 2010). Taken together – this latest study and previous published papers explain the mechanism as to how EVNol SupraBio™ may help in promoting hair growth in subjects experiencing hair loss,” says Bryan See, Business Development Manager, ExcelVite.
At Vitafoods Asia 2017, NutraIngredients-Asia’s Editor-in-Chief Gary Scattergoat interviewed ExcelVite to find out about the latest market trend and research for EVNol SupraBio™ bioenhanced full spectrum palm tocotrienol complex. Watch the interview at NutraIngredients-Asia’s website now.