Tocotrienol Research

EVNol SupraBio™ (Tocotrienol)
Clinical Research

Existing clinical research shows that natural full spectrum palm tocotrienol complex has beneficial effects in supporting brain, liver, heart, skin health, and hair growth.

Over 1000 research papers are listed on Pubmed for tocotrienol, however, this represents less than 1 percent of the overall number of research papers for the other vitamin E counterpart – tocopherol. Despite small number of research papers, the findings of tocotrienol in human studies are profound and significantly more superior if compared to tocopherol.

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Clinical Studies

EVNol SupraBio™ has been used in many clinical studies with various doses of tocotrienols that are well tolerated in humans. Subjects involved in all the published clinical studies below never reported any adverse events with daily dosage up to 400mg for the duration of up to 2 years.

YearStudyDosage of EVNol SupraBio™Indication
2021A phase IIb randomized controlled trial investigating the effects of tocotrienol-rich vitamin E on diabetic kidney disease200mg (Twice a day)Serum Creatinine Level in Diabetic Nephropathy During 12 months Supplementation and After Washout Period
2020The effects of tocotrienol-rich vitamin E (Tocovid) on diabetic neuropathy: a phase II randomized controlled trial200mg (Twice a day)Aspirin Resistance in Patients on Blood Thinning Drugs
2019Effects of tocotrienol supplementation in Friedreich’s Ataxia: a model of oxidative stress pathology256mg (EVNol SupraBio™ -encapsulated in softgel branded as OXI-3)Gene Expression of Antioxidant Enzymes in Friedreich’s Ataxia Patients
2019Tocotrienol-rich vitamin E improves diabetic nephropathy and persists 6–9 months after washout: a phase IIa randomized controlled trial200mg (Twice a day)Serum Creatinine Level in Diabetic Nephropathy During Supplementation and After Washout Period
2018Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy: A Randomized Clinical Trial200mg (Twice a day)Lancinating Pain in Diabetic Peripheral Neuropathy
2016Safety Assessment of Tocotrienol Supplementation in Subjects with Metabolic Syndrome: A Randomized Control Trial200mg (Twice a day)Supplementation safety in metabolic syndrome