Tocotrienol Research

EVNol SupraBio™ (Tocotrienol) Clinical Research


Existing clinical research shows that natural full spectrum palm tocotrienol complex has beneficial effects in supporting brain, liver, heart, skin health, and hair growth.

Over 1000 research papers are listed on Pubmed for tocotrienol, however, this represents less than 1 percent of the overall number of research papers for the other vitamin E counterpart – tocopherol. Despite small number of research papers, the findings of tocotrienol in human studies are profound and significantly more superior if compared to tocopherol.

Clinical Studies

EVNol SupraBio™ has been used in many clinical studies with various doses of tocotrienols that are well tolerated in humans. Subjects involved in all the published clinical studies below never reported any adverse events with daily dosage up to 400mg for the duration of up to 2 years.

Research updates : EVNol SupraBio™ on health conditions associated with diabetes

Watch webinar : Research on Super Vitamin E Tocotrienol and metabolic health

 2019 Tocotrienol-rich vitamin E improves diabetic nephropathy and persists 6–9 months after washout: a phase IIa randomized controlled trial 5412 weeks 200mg (twice a day) Serum Creatinine Level in Diabetic Nephropathy During Supplementation and After Washout Period 
2018Tocotrienol-rich Vitamin E from Palm Oil (Tocovid) and its Effects in Diabetes and Diabetic Nephropathy: A Pilot Study528 weeks200mg (twice a day)Serum Creatinine Level in Diabetic Nephropathy
2018Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy: A Randomized Clinical Trial30012 months200mg (twice a day)Lancinating Pain in Diabetic Peripheral Neuropathy
2016Safety Assessment of Tocotrienol Supplementation in Subjects with Metabolic Syndrome: A Randomized Control Trial312 weeks200mg (twice a day)Supplementation safety in metabolic syndrome

Potential of Mixed Tocotrienol Supplementation to Reduce Cholesterol and Cytokines Level in Adults with Metabolic Syndrome

7016 weeks200mg (twice a day)Metabolic syndrome (chronic inflammation)

Clinical investigation of the protective effects of palm vitamin E tocotrienols on brain white matter Unique identifier: NCT00753532.

1212 years200mg (twice a day)Brain/cognitive health
2013The effect of vitamin E (mixed tocotrienol) on the liver stiffness measurement measured by transient elastography (FibroScan) among NAFLD patients673 months50 mg (twice a day)Liver health
2013Tocotrienols for normalization of hepatic echogenic response in nonalcoholic fatty liver: a randomized placebo-controlled clinical trial 871 year200mg (twice a day)Liver health
2012Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients 4812 weeks200mg (twice a day)Liver health, Tissue Distribution
2011Tocotrienol vitamin E protects against preclinical canine ischemic stroke by inducing arteriogenesis*2010 weeks200mg (twice a day)Post stroke protrection (Pre-clinical trial)
2011Effects of mixed-tocotrienols in hypercholesterolemic subjects326 months300mg dailyHeart health
2010Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers1082 months400mg dailyVaccine Immunity
2010Effects of tocotrienol supplementation on hair growth in human volunteers388 months50mg (twice a day)Hair health
2008Arterial compliance and vitamin E blood levels with a self-emulsifying preparation of tocotrienol rich vitamin E 362 months50, 100 & 200mg dailyHeart health
2007Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects14012 weeks30 mg of Tocotrienols (EVNol™) with 270mg polymethoxyflavones (twice a day)Cholesterol, Heart health
2007Comparative study of the effect of tocotrienols and alpha-tocopherol on fasting serum lipid profiles444 weeks 50mgHeart health
2007Tocotrienols and Hair Growth FormulationU.S. Patent No. US 7211274 B2195 months50mg (twice a day)Hair health
2006Postprandial levels of the natural vitamin E tocotrienol in human circulation4Single dose of administration400mg Tocotrienols level in blood plasma
2004Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations  6Single dose of administration  200mg (once a day) Bioavailability
2002Cosmetic benefit of dietary supplements including astaxanthin and tocotrienol on human skin 164 weeks40mg of Tocotrienols (EVNol™)+2mg Astaxanthin (once daily)Skin health

(*) This is a study on large animal model (canine), a Preclinical Study funded by the US-NIH.

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Disclaimer: The statements in the above article have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure or prevent any disease.