Tocotrienol Research

EVNol SupraBio™ (Tocotrienol) Clinical Research

EVNol_SupraBio_Clinically-ResearchedExisting clinical research shows that natural full spectrum palm tocotrienol complex has beneficial effects in supporting brain, liver, heart, skin health, and hair growth.

Over 1000 research papers are listed on Pubmed for tocotrienol, however, this represents less than 1 percent of the overall number of research papers for the other vitamin E counterpart – tocopherol. Despite small number of research papers, the findings of tocotrienol in human studies are profound and significantly more superior if compared to tocopherol.

Clinical Studies

EVNol SupraBio™ has been used in many clinical studies with various doses of tocotrienols that are well tolerated in humans. Subjects involved in all the published clinical studies below never reported any adverse events with daily dosage up to 400mg for the duration of up to 2 years.

 2019 Tocotrienol-rich vitamin E improves diabetic nephropathy and persists 6–9 months after washout: a phase IIa randomized controlled trial  54 12 weeks  200mg (twice a day)  Serum Creatinine Level in Diabetic Nephropathy During Supplementation and After Washout Period 
2018 Tocotrienol-rich Vitamin E from Palm Oil (Tocovid) and its Effects in Diabetes and Diabetic Nephropathy: A Pilot Study 52 8 weeks 200mg (twice a day) Serum Creatinine Level in Diabetic Nephropathy
2018 Efficacy of Oral Mixed Tocotrienols in Diabetic Peripheral Neuropathy: A Randomized Clinical Trial 300 12 months 200mg (twice a day) Lancinating Pain in Diabetic Peripheral Neuropathy
2016 Safety Assessment of Tocotrienol Supplementation in Subjects with Metabolic Syndrome: A Randomized Control Trial 31 2 weeks 200mg (twice a day) Supplementation safety in metabolic syndrome

Potential of Mixed Tocotrienol Supplementation to Reduce Cholesterol and Cytokines Level in Adults with Metabolic Syndrome

70 16 weeks 200mg (twice a day) Metabolic syndrome (chronic inflammation)

Clinical investigation of the protective effects of palm vitamin E tocotrienols on brain white matter Unique identifier: NCT00753532.

121 2 years 200mg (twice a day) Brain/cognitive health
2013 The effect of vitamin E (mixed tocotrienol) on the liver stiffness measurement measured by transient elastography (FibroScan) among NAFLD patients 67 3 months 50 mg (twice a day) Liver health
2013 Tocotrienols for normalization of hepatic echogenic response in nonalcoholic fatty liver: a randomized placebo-controlled clinical trial 87 1 year 200mg (twice a day) Liver health
2012 Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients 48 12 weeks 200mg (twice a day) Liver health, Tissue Distribution
2011 Tocotrienol vitamin E protects against preclinical canine ischemic stroke by inducing arteriogenesis* 20 10 weeks 200mg (twice a day) Post stroke protrection (Pre-clinical trial)
2011 Effects of mixed-tocotrienols in hypercholesterolemic subjects 32 6 months 300mg daily Heart health
2010 Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers 108 2 months 400mg daily Vaccine Immunity
2010 Effects of tocotrienol supplementation on hair growth in human volunteers 38 8 months 50mg (twice a day) Hair health
2008 Arterial compliance and vitamin E blood levels with a self-emulsifying preparation of tocotrienol rich vitamin E 36 2 months 50, 100 & 200mg daily Heart health
2007 Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects 140 12 weeks 30 mg of Tocotrienols (EVNol™) with 270mg polymethoxyflavones (twice a day) Cholesterol, Heart health
2007 Comparative study of the effect of tocotrienols and alpha-tocopherol on fasting serum lipid profiles 44 4 weeks  50mg Heart health
2007 Tocotrienols and Hair Growth FormulationU.S. Patent No. US 7211274 B2 19 5 months 50mg (twice a day) Hair health
2006 Postprandial levels of the natural vitamin E tocotrienol in human circulation 4 Single dose of administration 400mg Tocotrienols level in blood plasma
2004 Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations  6 Single dose of administration   200mg (once a day)  Bioavailability
2002 Cosmetic benefit of dietary supplements including astaxanthin and tocotrienol on human skin 16 4 weeks 40mg of Tocotrienols (EVNol™)+2mg Astaxanthin (once daily) Skin health

(*) This is a study on large animal model (canine), a Preclinical Study funded by the US-NIH.

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Disclaimer: The statements in the above article have not been evaluated by the Food and Drug Administration. They are not intended to diagnose, treat, cure or prevent any disease.